ch of these heterocycli drugs is likely to be the least soluble in water? Use parameter to decide. Tramadol Chemical Formula: C16H25NO2 NH YOUR Ou Pantoprazole Torasemide Chemical Formula: C16H20403S Chemical Formula: C16H15F2N₂O4S Temazepam Chemical Formula: C16H13CIN₂02 Tioconazole Chemical Formula: C16H13jN₂ Fspº A. Tramadol B. Pantoprazole C. Torasemide D. Temazepam E. Toconazole
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- For 4-aminosalycilic acid please pick only the second choice phase 2 metabolite per handle present in the drug: OH H,N 4-Aminosalicylic acid OH إختر واحدة أو أكث OH OH NH, HN HO. OH HN HN он HO HO он HQ HO. HO. HNWhat is the oligodynamic effect? To which chemicals does the term oligodynamic effect apply? Give 2 examples of antiseptics based upon the oligodynamic effect.Discuss the suitability of bromocresol green and thymol blue (2nd change only) for use as indicators in an acetic acid - sodium hydroxide titration. Paragraph в I A + v ...
- Chitinase is a protein that breaks down chitin, a primary component of the cell wall in fungi, scales in fish and exoskeletons of arthropods. The activity of chitinase extracted from a plant was shown to be optimum at pH 5. You were tasked to prepare 300 mL of 150 mM buffer solution for further analysis of the extracted chitinase. REAGENTS Ka 2.5M Acetic acid Solid NaOAc•3H2O [136.08g/mol] 1.76 x 10-5 2.5M NH3 Solid NH4Cl [53.49g/mol] 5.6 x 10-10 2.5M Lactic acid Solid sodium lactate [112.06g/mol] 4.0 x 10-5 5 M HCl 5M NaOH Pls show sol'ns 1. Given the following reagents, give the moles of each component (acid & base).2. What are the mass/volume of the components needed to prepare the buffer? 3. What will the pH of the buffer be if 1mL of 5 M NaOH was added?CHM3413-Neutral vs lonized... consider the table of drugs shown below and their respective pka value(s). Complete the table by drawing the relevant portion of the drug molecule in its IONIZED form. Indicate whether the ion is the conjugate acid or conjugate base of the neutral drug, if two pka values are listed, then two ionized structures must be drawn. Drug Name: Neutral Form (Neutral) pka from table HA BH+ 5.4 9.5 Baclofen Captopril Ampicillin 3.7 M 9.8 2.5 7.2 Doxycycline 3.4 9.5 7.7 H H₂C HS 1,0 NH₂ Pho OH OH NH H OH S CH₂ NCH₂ OH 0 150 ONN-C H OH 0 CON 6 M lonized Form(s) Is/are the ION(s) a conj. acid or conj, base? CA or CB? % ionized at physiological pH?Using DEAE-cellulose as ion exhange resin, indicate the starting and ending pH for the narrowest experimental pH range used to seperate an amino acid mixture consisting of Ala, Cys and His Starting pH: Ending pH:
- Which physicochemical properties are useful for prediction of the oral bioavailability of drug molecules? Use naproxen and propranolol as examples in your answer.An amino acid mixture consisting of lysine, leucine, and glutamic acid is to be separated by ion-exchange chromatography, using a cationexchange resin at pH 3.5, with the eluting buffer at the same pH. Which of these amino acids will be eluted from the column first? Will any other treatment be needed to elute one of these amino acids from the column?Based on the USP XXII and NF XVIII, list the part of a monograph of the following: crude drug, natural product, and natural derivatives. The given question to me is: What is a pharmacopeial monograph? Based on the USP XXII and NF XVIII, list the part of a monograph of the following: crude drug, natural product, and natural derivatives.
- What is the United States Pharmacopeia requirement for the pH different antacid preparation?Propose a reasonable synthetic route for the preparation of the substituted benzene derivative shown below. You may use whatever reagents are necessary to transform the starting molecule into the desired product. CH(CH3)2 step 1 step 2 step 3 čOH Step 1 reagent/reagents %3D Step 2 reagent/reagents %3D Step 3 reagent/reagents80mL of a 0.3M solution of hexapeptide Leu-His-Cys-Glu-Asn-Arg is adjusted to pH=pI. The solution is then titrated with 0.2M HCL to a final pH of 2.1. Sketch the titration curve, labelling the pH and volume axes. Indicate the volume of HCL needed to reach relevant pKa value and equivalence point(s)z Relevant pKa values are: 2.1, 4.3, 6.0, 8.3, 9.8, and 12.5.