Felodipine calcium channel blocker standard (0.251mg/ml) and felodipine sample (0.245mg/ml) solutions were prepared and injected to the HPLC. The peak area of felodipine standard is 275428 and the sample is 272982. The potency (purity) of felodipine standard is 98.9%. What is the assay percentage of felodipine? a. 102.23 b. 98.71 c. 101.07 d. 100.42
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- If an instrument gives a response of 1240 for a standard containing 8 ppm of a substance, how much if this substance is in a sample that gives a response of 1705? Are any assumptions needed?Suppose a difference in changes in plasma oxytocin levels between two groups of 0.2 pg/mL would be of interest to researchers and that changes within each group have standard deviation o = 0.1 pg/mL. The power of a one-sided two-sample t-test to detect a difference in changes in oxytocin levels of 0.2 pg/mL between two groups of 5 women at the 5% level is25 ml of pickled brine was taken from an apple pickled with vinegar and diluted to 500 ml, 25 ml of this was taken and acidity was determined with 0.2 N (Factor: 1.05) NaOH. In the main trials, 6.3 ml - 6.5 ml - 6.9 ml, respectively, 0.1 ml base was used in the analysis without using the sample.For example, how many ppm is its acidity?
- Sheet 5 From the following data determine the following: Define outlier and then identify the outlier in the data. Determine if the outlier should be kept of discarded from the data. Trial 1 2 3 4 HCl (mL) 22.3 28.4 29.8 29.3 NaOH (mL) 35.2 35.1 34.9 35.0Table 2: Absorbance Values of Standards and Unknowns. Sample Blank Standard Solution 1 Standard Solution 2 Standard Solution 3 Standard Solution 4 Standard Solution 5 Water Sample 1 Water Sample 2 Phosphate Concentration (in ppm) Y17 0 ppm 0.02 ppm 0.04 ppm 0.08 ppm 0.16 ppm 0.32 ppm Freeman Lake 0.001 0.325 0.292 0.413 0.315 0.039 0.054 0.049 Absorbance at 2= 690 nm Calculations: 1. Construct a phosphate standard curve in Excel by plotting concentration (in ppm) on your x-axis and Absorbance (unitless) on your y-axis for your known solutions. Label the axes on the graph and provide the curve with a title. Use a linear trendline to generate a best fit line to your data. Label the graph with the equation and the R" value. Insert your labeled graph in the space below. Xpercentage purity of an ibuprofen sample was determined by a reversed phase HPLC method as follows: Y Der ● A calibration curve of peak area versus concentration (ug/mL) of pure ibuprofen was constructed The ibuprofen sample for analysis was prepared by taking 10.0204 g of powder and dissolving it in/1Lbf distilled water (solution A). 1 ml of the latter solution was further diluted to IL with distilled water (solution B). Solution B was analysed by HPLC analysis Results The equation for the best-fit line of the calibration curve is: y=26820x-1323.8. ● The average peak area for the ibuprofen sample (solution B) was 266796.2 Calculate the percentage purity of the ibuprofen powder.
- In the acetic acid determination in vinegar experiment; NaOH was standardized with 0.35 g KHP (molar mass = 204.22 g/mol). The KHP was dissolved in 75.0 mL distilled water in a 250 mL Erlenmeyer flask and titrated to the endpoint colour by dispensing 11.40 mL of NaOH from the burette. Calculate the molarity of NaOH. a. 0.10 М b. 0.15 M с. 0.20 М d. 0.35 M e. 0.25 М. 100 ml boiled cooled and filtered water sample takes 9.6 ml of M/50 EDTA in titration. The Permanent hardness of the water sample in terms of ppm of CaCO3 equivalent isAn analysis of city drinking water for total hardness was done by two students in the laboratory and produced the following results (in ppm CaCO3): Student A: 228.3, 226.4, 226.9, 227.1, and 228.6. Student B: 229.5, 226.1, 230.7, 223.8, and 227.5 what is the coefficient variation?
- A volume of 250 ml of a 0.05 M solution of a reagent of formula weight (relative molecular mass) 40 was made up, the weighing being done by difference. The standard deviation of each weighing was 0.0001 g. The standard deviation of the volume of solvent used was 0.05 ml. Express this as a relative standard deviation. Hence calculate the relative standard deviation of the molarity of the solution.Table 1: The result for test tube 1 to 8 using of BSA stock solution. Tube BSA Cone H;O (ml) BSA (ml) Biuret ABS mg/ml reagent (ml) 1. 1.0 4. 0. 2. 0.9 0.1 4. 0.003 3. 2. 0.8 0.2 4. 0.012 4. 3. 0.7 0.3 4. 0.021 5. 4. 0.6 0.4 4. 0.028 6. 0.5 0.5 4. 0.039 7. 6. 0.4 4. 0.042 8. 7. 0.3 0.7 4. 0.052 Table 2: The result for test tube 9 to 12 using of Unknown solution Protein Tube Uknown (ml) H;0 (ml) Biuret reagent ABS concentration (mg/ml) (ml) 9. 4. 0.036 10. 4. 0.035 11. 0.5 0.5 4. 0.017 12. 0.5 0.5 4 0.016 In order to determine the actual concentration of protein in the unknown samples it is necessary to draw the standard curve (concentration on the x-axis and on the absorbance y- axis) and interpolate the absorbance values of the unknowns. Draw graph and find protein concentration(mg/ml)The concentration of purified OXA-M290 is tested with a BCA assay. Serial dilutions of a bovine serum albumin (BSA) stock solution are prepared, then pipetted into a 96-well plate; each dilution of the BSA standard is tested in triplicate. Then, bicinchoninic acid and Cu2+ ions are added to all of the wells of the plate. After incubating the plate for 1 hour, a microplate reader is used to measure the absorbance of all of the wells in the plate at 560 nm. This generates the following data: BSA conc. (μg/mL), Replicate 1 Absorbance, Replicate 2 Absorbance, Replicate 3 Absorbance 40, 1.360, 1.403, 1.481 20, 0.750, 0.745, 0.810 10, 0.380, 0.344, 0.398 5, 0.198, 0.160, 0.183 2.5, 0.090, 0.100, 0.085 1.25, 0.038, 0.043, 0.051 0.625, 0.024, 0.028, 0.019 Prepare a calibration curve using these data. You can use Excel, R, SPSS or an equivalent graphing software. In this graph, plot absorbance (y-axis) against the concentration of the protein standard (x-axis). Calculate and plot…