Glycogenesis occurs in both muscle and liver. Select one: O True O False Glycogen is released from the muscle due to increased CAMP due to: Select one: O a. Growth hormone O b. Epinephrine O c. Thyroxine O d. Glucagon UDP-Glucose is converted to UDP-glucoronic acid by: Select one: O a. NADP O b. ATP O c. GTP O d. FAD Oe. NAD In the fasted state gluconeogenesis is promote by which enzyme Select one: O a. Fructose 2,6 bisphosphate induced stimulation of phosphofructokinase-1 O b. Acteyl CoA induced stimulation of pyruvate carboxylase O c. Citrate induced stimulation of Acetyl CoA decarboxylase Glyconeogenesis prevents hypoglycemia during prolonged fasting. Select one: O True O False
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- Based on your understanding of the binding of insulin, select all of the following events that you would expect to occur in muscle cells due to insulin binding to receptors.Group of answer choices a. Glycogen synthesis is activated b. PFK is stabilized in the R-state and glycolysis is activated c. GLUT4 (transporters) are increased in concentration at the plasma membrane d. Fructose 2,6-bisphosphate increased levels aid in stabilization of the T-state fructose 1,6-bisphosphatase e. Gluconeogenesis is activated in response to elevated fructose 2,6-bisphosphate levels f. Phosphorylation cascades allow for covalent modifications that would aid in the breakdown of glycogen to allow for increased levels of glucose 6-phosphate in the cell g. Hexokinase is inhibited so glucose will not be brought into the cell in high amounts h. Glycogen breakdown pathway is inactivatedWhich of the following activate glycogen synthesis? A. Phosphorylation of glycogen synthase kinase 3 B. Activation of protein kinase A (PKA) C. Both A and B D. Neither A nor B Assuming that glucokinase is completely inhibited, which of the following statements is correct? Glycolysis reactions beyond glucose-6-phosphate in the liver would be impossible to take place The Cori cycle would be blocked Both A and B Neither A nor BIn muscle, glycogen phosphorylase is stimulated (activated) by a. Glucose b. AMP c. Glucose 6-phosphate d. ATP
- Epinephrine binding allows the "fight-or-flight" response. Think about how this would differ from insulin binding. In the muscle, what would you expect for pathways use of glucose 6-P? Select all that apply. a. Glycogen breakdown is activated to produce glucose 6 - phosphate b. Glucose 6-phosphatase is activated to allow glucose release from muscle cell c. Pyruvate kinase is stabilized in the T-state d. Glycogen synthesis is activated e. PRK is stabilized in the R-state, glycolysis is activatedAfter eating a large meal, which one of the following events would NOT happen? A. Increased glycolysis in liver B. Increased glycogen phosphorylase activity O C. Decreased phosphorylase kinase activity O D. Decreased GSK-3 activity E. Increased insulin levels in bloodInsulin therapy has all of the following effects, except:A. Increases concentration of free fatty acids in blood plasma B. Stimulates glucose uptake by tissuesC. Inhibits lipolysisD. Activates protein synthesis
- A 30 year old man who has type I diabetes mellitus with a blood glucose of 340 mg. One hour after eating he administered a dose of short acting insulin. After treatment what is most likely increased in the liver? a. cAMP b. G6P activity c. PFK 1 d. phosphorylation of pyruvate kinase e. PKACHOOSE THE CORRECT LETTER When glycogen is synthesized in both the liver and muscle, all the following are true, EXCEPT A.Glucose is transferred from UDP-glucose to a growing glycogen molecule by glycogen synthase.B. Phosphoglucomutase converts glucose 6-phosphate to glucose 1-phosphateC. Glucose 6-phosphate is converted to glucose by a phosphatase.D.Glucose 1-phosphate is activated by UDP-glucose pyrophosphorylase to produce UDP-glucose and PPi.The synthesis and degradation of glycogen in muscle is not a futile (ATP-hydrolyzing)cycle because:A. glycogen synthase and phosphorylase are simultaneously activatedB. cyclic AMP activates adenylate kinase. C. when glycogen synthase is inactivated, phosphorylase is simultaneously activated. D. glycogen binds Mg2+, thereby lowering the concentration of MgATP2-
- which of the following are possible sources of glyceraldehyde 3-phosphate a. more than 1 correct response b. 2 moles of glucos c. cleavage of fructose-1-6-biphosphate d. dihydroxyacetone phosphateA deficiency in sorbitol dehydrogenase cause all of the following except: Select one: O a. pathologic alternations related to Diabetes mellitus b. no lactose synthesis O c. lack of sperm motility O d. no fructose synthesisWhich of the following statements concerning gluconeogenesis is NOT true? a. Gluconeogenesis is to make glucose from glycogen. b. Many of the reactions of gluconeogenesis are glycolytic reactions going in reverse. c. The process of gluconeogenesis consumes ATP. d. The process of gluconeogenesis is regulated by ATP. e. Gluconeogenesis maintains the blood glucose level long after all dietary glucose has been absorbed and oxidized.