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- Figure 10.6 Which of the following is the correct order of events in mitosis? Sister chromatids line up at the metaphase plate. The kinetochore becomes attached to the mitotic spindle. The nucleus reforms and the cell divides. Cohesin proteins break down and the sister chromatids separate. The kinetochore becomes attached to the mitotic spindle. Cohesin proteins break down and the sister chromatids separate. Sister chromatids line up at the metaphase plate. The nucleus reforms and the cell divides. The kinetochore becomes attached to the cohesin proteins. Sister chromatids line up at the metaphase plate. The kinetochore breaks down and the sister chromatids separate. The nucleus reforms and the cell divides. The kinetochore becomes attached to the mitotic spindle. Sister chromatids line up at the metaphase plate. Cohesin proteins break down and the sister chromatids separate. The nucleus reforms and the cell divides.Figure 28.11 depicts the eukaryotic cell cycle. Many cell types “exit� the cell cycle and don’t divide for prolonged periods, a state termedG0; some, for example neurons, never divide again. a. In what stage of the cell cycle do you suppose a cell might be when it exits the cell cycle and enters G0? b. The cell cycle is controlled by checkpoints, cyclins, and CDKs. Describe how biochemical events involving cyclins and CDKs might control passage of a dividing cell through the cell cycle.28. 28. Which of the following would be expressed at approximately equal levels throughout the cell cycle? Kinetochore proteins Cyclins Cohesins Cyclin-dependent kinases
- Which of the following statement is NOT true? Cell cycle cyclin dependent kinases (CDKs) are synthesized and degraded in every cell cycle O Activity of the S phase CDKs rise in the S phase and drops in the G2 and mitotic phase APC/C proteasome activity increases during mitotic phase and drops towards the end of the G1 phase G1/S cyclin protein amount rises in the G1 phaseWhich one of the following statements best describes the mechanism by which the "cell cycle control system" regulates events of the cell cycle? O Hydrophobic signaling molecules cross the plasma membrane at distinct stages in the cell cycle O Ca++ and CAMP release into the nucleus signal the progression of the cell cycle Changes in vesicle trafficking events signal progression of the cell cycle Changes in the cellular cytoskeleton signal progression of the cell cycle Protein phosphorylation and dephosphorylation events signal the progression of the cell cycleIn mammalian cells, different cyclin-CDK complexes regulate progression of cells through the cell cycle. Which of the following would be true during the cell cycle? Select all that apply Cyclin D phosphorylates and activates MCM protein, a helicase Cyclin B phosphorylates and breaks down the nuclear lamina OThe anaphase promoting complex, or APC/C is phosphorylated and activated by cyclin B Cyclin D helps promotes passage through the restriction point
- The checkpoint permits cell entry into mitosis only if all DNA is replicated.* Start APC/C G2/M G1/S A hydrogen atom is sometimes referred to as a proton because O It is positively charged It is negatively charged It has just one proton It has just one electron How many chromosomes are in a human sex cell right after meiosis I? * O 46 O 23 92 4 Which protein family is responsible for facilitating the process of programmed cell death that is activated in cells with significant DNA damage? * O Separase OCaspase Cdk-cyclin OShugoshin O O O O O O O OTaxol is an anticancer drug extracted from the Pacific yew tree. In animal cells, Taxol disrupts microtubule formation. Surprisingly, this stops mitosis. Specifically, Taxol must affect formation of the centrioles the structure of the mitotic spindle chromatid assembly anaphase O00OWhich of the following would result in cell cycle arrest? O phosphorylation of Rb by G1-Cdk phosphorylation of p53 O phosphorylation of helicase by S-Cdk phosphorylation of M-Cdk by CAK phosphorylation of APC by M-Cdk
- Which of the following statements correctly describes how cells progress through the various stages of the cell cycle? Controlled expression and degradation of both cyclins and cdks Controlled expression and degradation of only cyclins Fixed time frame for each phase of the cell cycle independent of protein expression O Controlled expression and degradation of only cdksCell cycle checkpoints are surveillance mechanisms that monitor the integrity and fidelity of the major events of the cell cycle. Which of the following are true about cell cycle checkpoints? Select all that apply The M phase checkpoint examines whether all sister chromatids are correctly attached to the spindle microtubules Progression through checkpoints is determined by the activation of cyclin dependent kinases bound to cyclins The G2 checkpoint is also called the restriction checkpoint O If a cell passes the G1 checkpoint, it irreversibly commits to complete the whole cell cycle and divideImagine that a cell contains a temperature-sensitive mutation such that nuclear lamins cannot be phosphorylated at the restrictive temperature. Describe the phenotype of the mutant cells during mitosis at the restrictive temperature. O The mutant cells will not be able to decondense chromosomes and will be arrested in prophase O The mutant cells will not be able to assemble the mitotic spindle and will be arrested in metaphase O The mutant cells will not be able to disassemble the nuclear envelope and will be arrested in prophase The mutant cells will go through multiple mitotic cycles without cytokinesis and will become multi-nucleated The mutant cells will be unable to reassemble the nuclear envelope and will be arrested in telophase
