Which of the following are ligands bound to the porphyrin ring Fe(II) ion in oxymyoglobin? His E7 (the distal his) His F8 (the proximal his) Nitrogen atoms in the porphyrin ring Oxygen BPG
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- One of the following glycosaminoglycans is anti-coagulant O Heparin sulphate O Keratan sulphate O Chondroitin sulfate O Hyaluronic acid O Heparan sulphateWhy is salbutamol better than isoproterenol in asthma management in terms of their binding sites?One of the following glycosaminoglycans is anti-coagulant O Heparan sulphate O Hyaluronic acid O Heparin sulphate O Keratan sulphate O Chondroitin sulfate search
- Which of the following is false about chymotrypsin? A Hydrolytic cleavage of a peptide bond by chymotrypsin involves two nucleophilic attacks to the substrate B It is activated in the presence of trypsin C It is synthesized in the thyroid gland D Polypeptide chains in chymotrypsin are linked by S-S bondsAbout defroxamine (all are correct except Select one: 1- its a tridentate chelating agent of great water solubility as well as stability forming a hexagonal complex 2- due to its poor GIT absorption administered as I.M and I.V injection 3- the precursor is a ferric ion natural product obtained from the bacteria Streptomuces pilosis modified through removal of iron III then converted as mesylate salt 4- it is a water instable compound produced as injectable powder for instant reconstitution used to treat hemochromatosisThe hexapeptide Ala-Met-Leu-Lys-Phe-Asp is digested in the same tube with both Cyanogen Bromide and Trypsin at the same time at pH=7. Draw the structure of the product(s) that would bind to a cation exchange column. (Relevant pKa values are 2.2, 3.9, 9.5 and 10.5. Assume pKa values for any newly generated a-amino and a-carboxyl groups are 9.5 and 2.2 respectively)
- Which of the following statements is not true about the catalytic triad in chymotrypsin? Group of answer choices the side chain of the serine 195 is hydrogen bonded to the imidazole ring of histidine the -NH group of the imidazole ring of histidine is hydrogen bonded to the carboxylate group of aspartate 102 the histidine residue serves to position the aspartate 102 side chain and to polarize its carboxylate group so that it is poised for deprotonation histidine acts as a general base catalyst none of theseWhich of these heterocyclic drugs is likely to be the least soluble in water? Use the Fsp³ parameter to decide. OH Tramadol Chemical Formula: C16H25NO2 YOUR OW Pantoprazole Torasemide Chemical Formula: C16H15F2N3O4S Chemical Formula: C16H20N4O3S Temazepam -OH Chemical Formula: C16H13CIN₂O2 Tioconazole Chemical Formula: C16H13C3N₂OS A. Tramadol B. Pantoprazole C. Torasemide D. Temazepam E. ToconazoleWhat are the similarities and differences (*in terms of structure) between this analgesic and aspirin? What are the major advantage of this analgesic? Structure of analgesic is provided, please draw structure of aspirin too.
- Allosteric inhibitors of hemoglobin will decrease enzyme activity (oxygen binding) through which of the following mechanisms? Binding the enzyme in "T" conformation and displacing an activator Binding the enzyme and enhancing the Vmax Binding the enzyme, and keeping it in the "R" conformation Binding the enzyme, and keeping it in the "T" conformationConsider the synthesis and degradation of tyrosine as shown in Figures 25.37, 25.38, and 25.48 to determine where the carbon atoms in PEP and erythrose-4-P would end up in acetoacetate and fumarate.Dehydroascorbate is unstable at pH values greater than 6 anddecomposes to form tartrate and oxalate. Cells use GSH toreduce the loss of ascorbate. What is the reaction pathwayfor the regeneration of ascorbate?
