Microbiology with Diseases by Body System (5th Edition)
5th Edition
ISBN: 9780134477206
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Chapter 1, Problem 2CT
In 1911, the Polish scientist Casimir Funk proposed that a limited diet of polished white rice (rice without the husks) caused beriberi, a disease of the central nervous system. Even though history has proven him correct—beriberi is caused by a thiamine deficiency, which in his day resulted from unsophisticated milling techniques that removed the thiamine-rich husks—Funk was criticized by his contemporaries, who told him to find the microbe that caused beriberi. Explain how the prevailing scientific philosophy of the day shaped the point of view of Funk’s detractors.
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In 1971, Dr. Akira Endo, working at the
Sankyo company in Tokyo speculated that fungi not
only contained antibiotics but also inhibitors of other
processes such as cholesterol metabolism. Over a
period of several years, he screened more than 6,000
fungal cultures until a positive result emerged. This
compound, which was named compactin, came from
the blue-green mold Penicillium citrinum Pen-5 that
was isolated from a rice sample collected at a grain
shop in Kyoto. Based on biochemical assays,
compactin is the first known statin.
1. The original kinetics data for compactin inhibition
of HMG-CoA reductase enzyme that was published
by Dr. Endo in 1976 is shown on the right.
a) Determine the Km and Vmax values for enzymatic
activity. Do NOT forget the units. Answers can be
expressed either as a fraction or in decimals.
With No inhibitor:
; Vmax=
-60
1/V, (nanomoles/min)-1
0.4
0.35+
0.3
0.25
0.2
0.15
0.1
0.05
-40 -20 0
+ 24 nM compactin
+ 70 nM compactin
None
T
20 40 60
1/[HMG-CoA], (mM)-1…
Chapter 1 Solutions
Microbiology with Diseases by Body System (5th Edition)
Ch. 1 - Some people consider Leeuwenhoek the Father of...Ch. 1 - Prob. 1CCSCh. 1 - Some people consider Pasteur or Koch to be the...Ch. 1 - Variant Creutzfeldt-Jakob Disease Ellen screamed...Ch. 1 - Prob. 3TMWCh. 1 - Which of the following microorganisms are not...Ch. 1 - Prob. 2MCCh. 1 - In which habitat would you most likely find...Ch. 1 - Of the following scientists, who first promulgated...Ch. 1 - Which of the following scientists hypothesized...
Ch. 1 - Prob. 6MCCh. 1 - Prob. 7MCCh. 1 - Prob. 8MCCh. 1 - A scientist who studies the role of microorganisms...Ch. 1 - The laboratory of Robert Koch contributed which of...Ch. 1 - Fill in the Blanks 1. Environmental microbiology...Ch. 1 - Prob. 2FIBCh. 1 - Fill in the Blanks 3. Chemotherapy _______________Ch. 1 - Fill in the Blanks 4. Immunology _______________Ch. 1 - Fill in the Blanks 5. Infection control...Ch. 1 - Fill in the Blanks 6. Etiology _______________Ch. 1 - Fill in the Blanks 7. Epidemiology _______________Ch. 1 - Fill in the Blanks 8. Biotechnology...Ch. 1 - Fill in the Blanks 9. Food microbiology...Ch. 1 - Why was the theory of spontaneous generation a...Ch. 1 - Discuss the significant difference between the...Ch. 1 - List six types of microorganisms.Ch. 1 - Defend this statement: The investigations of...Ch. 1 - Why would a macroscopic tapeworm be studied in...Ch. 1 - Describe what has been called the Golden Age of...Ch. 1 - List four major questions that drive...Ch. 1 - Refer to the four steps in the scientific method...Ch. 1 - Prob. 9SACh. 1 - What does the term HAI (nosocomial infection) have...Ch. 1 - Match each of the following descriptions with the...Ch. 1 - Prob. 1VICh. 1 - Show where microbes ended up in Pasteurs...Ch. 1 - If Robert Koch had become interested in a viral...Ch. 1 - In 1911, the Polish scientist Casimir Funk...Ch. 1 - Haemophilus influenzae does not cause flu, but it...Ch. 1 - Just before winter break in early December, your...Ch. 1 - Design an experiment to prove that microbes do not...Ch. 1 - Prob. 6CTCh. 1 - Compare and contrast the investigations of Redi,...Ch. 1 - If you were a career counselor directing a student...Ch. 1 - A few bacteria produce disease because they derive...Ch. 1 - How might the debate over spontaneous generation...Ch. 1 - French microbiologists, led by Pasteur, tried to...Ch. 1 - Why arent Kochs postulates always useful in...Ch. 1 - Albert Kluyver said, From elephant to ......Ch. 1 - The ability of farmers around the world to produce...Ch. 1 - Using the following terms, fill in the following...
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