Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 3, Problem 9QP
Crossing Pea Plants: Mendel’s Study of Single Traits
Sickle cell anemia (SCA) is a human genetic disorder caused by a recessive allele. A couple plan to marry and want to know the probability that they will have an affected child. With your knowledge of
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Mendelian Genetics and Non-Mendelian Genetics: Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jillian is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Jacobwhose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibit sickle cell anemia.
1. Give the genotypes of Jillian and Jacob.
Assuming that they will have 4 children, what is the probability that:
2. all their children will be normal?
3. they will have a son with Huntington’s disease?
4. they will have a daughter inflicted with both conditions
Sickle cell anemia is a human genetic disorder caused by an autosomal recessive allele. A couple plan to marry and want to know the probability that they will have an affected child. With your knowledge of Mendelian inheritance, what can you tell them if (1) each has one affected parent and a parent with no family history of SCA or (2) the man is affected by the disorder but the woman has no family history of SCA?
Considering a common autosomal recessive trait:
(Read each statement carefully. Select all of the statements below that are true (that
you agree with). Leave any statements that are false (that you do not agree with) un-
selected.)
the unaffected biological siblings of an affected person should be heterozygotes.
an unaffected woman and an affected man have at most a 100% probability of
having a affected child.
an affected person should have an affected parent.
The unaffected offspring of an affected parent must be carriers.
Chapter 3 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 3.4 - Why do scientists design experiments to disprove...Ch. 3.4 - Should Ockhams razor be considered an irrefutable...Ch. 3.7 - Prob. 1EGCh. 3.7 - For most cases, a p value of 0.05 is used to...Ch. 3 - Prob. 1CSCh. 3 - Prob. 2CSCh. 3 - Prob. 3CSCh. 3 - Prob. 1QPCh. 3 - Crossing Pea Plants: Mendels Study of Single...Ch. 3 - Crossing Pea Plants: Mendels Study of Single...
Ch. 3 - Prob. 4QPCh. 3 - Crossing Pea Plants: Mendels Study of Single...Ch. 3 - Prob. 6QPCh. 3 - Crossing Pea Plants: Mendels Study of Single...Ch. 3 - Crossing Pea Plants: Mendels Study of Single...Ch. 3 - Crossing Pea Plants: Mendels Study of Single...Ch. 3 - Crossing Pea Plants: Mendels Study of Single...Ch. 3 - Crossing Pea Plants: Mendels Study of Single...Ch. 3 - More Crosses with Pea Plants: The Principle of...Ch. 3 - More Crosses with Pea Plants: The Principle of...Ch. 3 - Prob. 14QPCh. 3 - More Crosses with Pea Plants: The Principle of...Ch. 3 - More Crosses with Pea Plants: The Principle of...Ch. 3 - Prob. 17QPCh. 3 - More Crosses with Pea Plants: The Principle of...Ch. 3 - More Crosses with Pea Plants: The Principle of...Ch. 3 - More Crosses with Pea Plants: The Principle of...Ch. 3 - More Crosses with Pea Plants: The Principle of...Ch. 3 - More Crosses with Pea Plants: The Principle of...Ch. 3 - Meiosis Explains Mendels Results: Genes Are on...Ch. 3 - Meiosis Explains Mendels Results: Genes Are on...Ch. 3 - Meiosis Explains Mendels Results: Genes Are on...Ch. 3 - Prob. 26QPCh. 3 - Prob. 27QPCh. 3 - Variations on a Theme by Mendel A characteristic...Ch. 3 - Prob. 29QPCh. 3 - Variations on a Theme by Mendel Pea plants usually...Ch. 3 - Prob. 31QPCh. 3 - Prob. 32QPCh. 3 - Prob. 33QPCh. 3 - Prob. 34QPCh. 3 - Prob. 35QPCh. 3 - Prob. 36QP
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- A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forward
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardCystic fibrosis is an autosomal disease that mainly affects the white population, and 1 in 20 whites are heterozygotes. Genetic testing can diagnose heterozygotes. Should a genetic screening program for cystic fibrosis be instituted? Should the federal government fund it? Should the program be voluntary or mandatory, and why?arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic disorder in a family, you are able to collect a four-generation pedigree that details the inheritance of the disorder in question. Analyze the information in the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedarrow_forward
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