Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 5, Problem 18P
Cinnabar eyes (cn) and reduced bristles (rd) are autosomal recessive characters in Drosophila. A homozygous wild-type female was crossed to a reduced, cinnabar male, and the F males were then crossed to the F females to obtain the F . Of the 400 F offspring obtained, 292 were wild type, 9 were cinnabar, 7 were reduced, and 92 were reduced and cinnabar. Explain these results and estimate the distance between the cn and rd loci.
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Black body (b) and purple eye (pr) are recessive autosomal mutations in Drosophila. Bridges are crossed b/b females with pr/pr males and in the F2 observed 684 wild type, 371 black-bodied, and 300 purple-eyed flies. Do these results indicate that the b and pr genes are closely linked? Explain. (Remember that there is no crossing-over in male Drosophila)..
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In Drosophila, a cross was made between females and wild-type males. The female parents
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Miniature wing, cinnabar eye
Ebony body
Miniature wing, ebony body
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(i)
Using proper nomenclature, determine the genotypes of the females and males in
generation P and F1.
(ii)
What is the correct order of the genes?
(iii)
Construct a genetic map showing the correct order and distances between these genes.
Chapter 5 Solutions
Genetics: From Genes to Genomes
Ch. 5 - Choose the phrase from the right column that best...Ch. 5 - a. A Drosophila male from a true-breeding stock...Ch. 5 - Prob. 3PCh. 5 - The Punnett square in Fig. 5.4 shows how Mendels...Ch. 5 - In mice, the dominant allele Gs of the X-linked...Ch. 5 - In Drosophila, males from a true-breeding stock...Ch. 5 - If the a and b loci are 20 m.u. apart in humans...Ch. 5 - CCDD and ccdd individuals were crossed to each...Ch. 5 - In mice, the autosomal locus coding for the...Ch. 5 - In a particular human family, John and his mother...
Ch. 5 - Albino rabbits lacking pigment are homozygous for...Ch. 5 - In corn, the allele A allows the deposition of...Ch. 5 - If the a and b loci are 40 cM apart and an AA BB...Ch. 5 - Write the number of different kinds of phenotypes,...Ch. 5 - A DNA variant has been found linked to a rare...Ch. 5 - Figure 5.7a shows chromosomes during prophase of...Ch. 5 - Figure 5.7b shows bivalents in mouse primary...Ch. 5 - Cinnabar eyes cn and reduced bristles rd are...Ch. 5 - In Drosophila, the autosomal recessive dp allele...Ch. 5 - From a series of two-point crosses, the following...Ch. 5 - Map distances were determined for four different...Ch. 5 - In the tubular flowers of foxgloves, wild-type...Ch. 5 - In Drosophila, the recessive allele mb of one gene...Ch. 5 - A snapdragon with pink petals, black anthers, and...Ch. 5 - In Drosophila, three autosomal genes have the...Ch. 5 - Drosophila females heterozygous for each of three...Ch. 5 - Male Drosophila expressing the autosomal recessive...Ch. 5 - a. In Drosophila, crosses between F1 heterozygotes...Ch. 5 - A true-breeding strain of Virginia tobacco has...Ch. 5 - Prob. 30PCh. 5 - The following list of four Drosophila mutations...Ch. 5 - Do the data that Mendel obtained fit his...Ch. 5 - Two genes control color in corn snakes as follows:...Ch. 5 - A mouse from a true-breeding population with...Ch. 5 - Neurospora of genotype a c are crossed with...Ch. 5 - A cross was performed between one haploid strain...Ch. 5 - Prob. 40PCh. 5 - Prob. 41PCh. 5 - Indicate the percentage of tetrads that would have...Ch. 5 - Prob. 43PCh. 5 - This problem leads you through the derivation of a...Ch. 5 - a. In ordered tetrad analysis, what is the maximum...Ch. 5 - Prob. 46PCh. 5 - A single yeast cell placed on a solid agar will...Ch. 5 - Figure 5.29 shows mitotic recombination leading to...Ch. 5 - A diploid strain of yeast has a wild-type...Ch. 5 - In Drosophila, the yellow y gene is near the...Ch. 5 - Neurofibromas are tumors of the skin that can...Ch. 5 - Two important methods for understanding the...
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- In a cross in Drosophila, a female heterozygous for the autosomallylinked genes a, b, c, d, and e (abcde/ + + + + +) was testcrossedwith a male homozygous for all recessive alleles (abcde/abcde).Even though the distance between each of the loci was at least3 map units, only four phenotypes were recovered, yielding thefollowing data: Phenotype No. of Flies+ + + + + 440a b c d e 460+ + + + e 48a b c d + 52 Total = 1000 Why are many expected crossover phenotypes missing? Can anyof these loci be mapped from the data given here? If so, determinemap distances.arrow_forwardMale Drosophila expressing the autosomal recessivemutations sc (scute), ec (echinus), cv (crossveinless),and b (black) were crossed to phenotypically wildtype females, and the 3288 progeny listed wereobtained. (Only mutant traits are noted.)653 black, scute, echinus, crossveinless670 scute, echinus, crossveinless675 wild type655 black71 black, scute73 scute73 black, echinus, crossveinless74 echinus, crossveinless87 black, scute, echinus84 scute, echinus86 black, crossveinless83 crossveinless1 black, scute, crossveinless1 scute, crossveinless1 black, echinus1 echinusa. Diagram the genotype of the female parent.b. Map these loci.c. Do the data provide evidence of interference?Justify your answer with numbers.arrow_forwardMale Drosophila from a true-breeding wild-type stock were irradiated with X-rays and then mated with females from a true-breeding stock carrying the following recessive mutations on the X chromosome: yellow body (y), crossveinless wings (cv), cut wings (ct), singed bristles (sn), and miniature wings (m). These markers are known to map in the order: Recessive alleles: y, cv, ct, sn, m Dominant alleles: y+, cv+, ct+, sn+, m+ y-cv-ct-sn-m у CV ct sn m X-rays х х X ct sn CV у m y+ CV+ ct+ sn+ m+ х X ? Exceptional female: Most of the female progeny of this cross were phenotypically wild type, but one female exhibited ct and sn mutant characteristics. When this exceptional ct sn female was mated with a male from the true-breeding wild-type stock, twice as many females as males appeared among the progeny. a. What is the nature of the X-ray-induced mutation present in the exceptional female? b. Draw the X chromosomes present in the exceptional ct sn female as they would appear during pairing…arrow_forward
- You are mapping three linked loci in Drosophila melanogaster (the common laboratory fruit fly). You cross flies that are triply mutant for apricot (pale eyes), bristle (extra bristles) and clipped (notched wings) to wild-type flies. The F+ flies are wild-type in appearance. You then backcross the F+ females to pure-breeding (apricot, bristle, clipped) males and score the phenotypes of 1000 F progeny for all three loci. Here are the results: 359 wild-type 361 apricot, bristle, clipped 89 bristle, clipped 91 apricot 42 apricot, bristle 38 clipped 9 apricot, clipped 11 bristle Using these data, first determine what gametes from the F; trihybrid produced each of the eight F2 categories. Note that apricot = aa (recessive to wild-type A); bristle = bb (recessive to wild-type B); and clipped = cc (recessive to wild-type C). Then determine if each gamete is recombinant (R) or nonrecombinant (R) for each pair of alleles (that is, for each genetic interval). Complete the table by dragging the…arrow_forwardThree recessive mutations in Drosophila melanogaster, roughoid (ru, small rough eyes), javelin (jv, cylindrical bristles), and sepia eyes (se, dark brown eyes) are linked. A three-point cross was carried out and the following progeny obtained: jv+ ru+ se+ 37 jv+ ru+ se 2 jv+ ru se 14 jv+ ru se+ 146 jv ru se+ 2 jv ru se 35 jv ru+ se 154 jv ru+ se+ 10 a. Determine the order of the genes on the chromosome. b. Determine which progeny contain single crossovers and which contain double crossovers and indicate where among the genes the crossovers occurred. c. Calculate the map distances among the genes. d. Calculate the coefficient of coincidence and interference among the genesarrow_forwardConsider the following three autosomal recessive mutations in Drosophila:vestigial wings (v); wild type is long (v+)black body color (b); wildtype is gray (b+)plum eyes (p); wildtype is red (p+)A vestigal, gray, red female (homozygous for all three genes) is crossed with a long wing, black, plum male (homozygous for all three genes). The F1 female progeny are mated with triple homozygous recessive males. Here is the phenotypic data for the F2 progeny:vestigal; gray; red 580long wings; black; plum 592vestigal; black; red 45long; gray; plum 40vestigal; black; plum 89long; gray; red 94vestigal; gray; plum 3long; black; red 5A total of 1448 progeny were counted.Which one of the following values is the approximate distance between the plum eye color and black body color loci?arrow_forward
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- Two Drosophila flies that had normal (transparent, long) wings were mated. In the progeny, two new phenotypes appeared, dusky wings (having a semi-opaque appearance) and clipped wings (with squared ends). The progeny were as follows: Females: 179 transparent, long 58 transparent, clipped Males: 92 transparent, long 89 dusky, long 28 transparent, clipped 31 dusky, clipped a) Provide a genetic explanation for these results, showing genotypes of parents and of all progeny classes under your model. b) Design a test for your model.arrow_forwardIn Drosophila fruit flies, the genes for warped wings (dwp), rumpled bristles (rmp), and pallid wings (pld) are linked. A trihybrid female for all three allleles is crossed with homozygous recessive male for all three alleles and the offspring obtained showed the following phenotypes: 3 pld rmp dwp 428 pld rmp + 427 + + dwp 48 + rmp + 47 pld + dwp 23 pld + + 2 + + + 22 + rmp dwp What is the order and map distance between these three alleles?arrow_forwardIt is assumed that in Drosophila the following genotypes produce phenotypes. َA- B- = Red color A- bb = Plum color aa B- = Magenta color aa bb = White color The third latent genotype, cc, kills homozygous Plums, but has no effect on other genotypes. Also, genotype C- does not produce a large phenotype. If first-generation Drosophilas are heterozygous for all of these genes and interbreed, what phenotypic ratios are expected in society?arrow_forward
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