About the feedback inhibition and the mechanism by which the figure 1 fits into the systems diagram, shown in figure 2. Given: The feedback inhibition mechanism of a metabolic pathway is represented in the form of a diagram as follows: The systems diagram representing different pathways and their intersections is represented in figure 2. A metabolic pathway catalyzed by an enzyme is represented by each line. Each node represents a metabolite (small molecule). Several metabolic pathways and metabolites intersect and overlap each other. Figure 2: A systems diagram representing complex interactions of several metabolic pathways, their points or intersection and overlap, which takes place inside the human body. Introduction: A feedback is the mechanism utilized by the end product of a reaction sends feedback about the continuity of reaction. It is the mechanism by which hormone in the blood/body is maintained. The mechanism can be positive or negative. The positive feedback mechanism consists of cycles when end product of a reaction sends feedback about continuity of reaction. For example, release of oxytocin hormone during childbirth. The negative feedback mechanism consists of cycles when end product of a reaction sends feedback about inhibition of reaction. For example, in case of insulin, hormone is used in regulation of glucose.

Question

The graphs 3 and 4 representing 1/Vo = f(1/[S]o) have been done in the presence of a competitive (CI) and noncompetitive inhibitor (NCI). a- For each figure, determine from the relative position of the straight lines which one is obtained in presence of an inhibitor. b- Indicate which graph corresponds to the competitive inhibition and which one the noncompetitive inhibition. Justify your answer. c- Complete the graphs by indicating which values can be determined from the arrows. 3 1/No 1/[S]⁰ (4) 1/No 1/[S]o

Answer 1

Question

Chapter 8.5, Problem 1R

Summary Introduction

To review:

About the feedback inhibition and the mechanism by which the figure 1 fits into the systems diagram, shown in figure 2.

Given:

The feedback inhibition mechanism of a metabolic pathway is represented in the form of a diagram as follows:

The systems diagram representing different pathways and their intersections is represented in figure 2.

A metabolic pathway catalyzed by an enzyme is represented by each line.

Each node represents a metabolite (small molecule).

Several metabolic pathways and metabolites intersect and overlap each other.

Figure 2: A systems diagram representing complex interactions of several metabolic pathways, their points or intersection and overlap, which takes place inside the human body.

Introduction:

A feedback is the mechanism utilized by the end product of a reaction sends feedback about the continuity of reaction. It is the mechanism by which hormone in the blood/body is maintained. The mechanism can be positive or negative. The positive feedback mechanism consists of cycles when end product of a reaction sends feedback about continuity of reaction. For example, release of oxytocin hormone during childbirth. The negative feedback mechanism consists of cycles when end product of a reaction sends feedback about inhibition of reaction. For example, in case of insulin, hormone is used in regulation of glucose.

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