The amount of caffeine in an analgesic tablet was determined by HPLC using a normal calibration curve. Standard solutions of caffeine were prepared and analyzed using a 10-uL fixed-volume injection loop. Results for the standards are summarized in the following table. Concentration, ppm 50.0 Peak Area 8 354 100.0 16 925 150.0 25 218 200.0 33 584 250.0 42 002 The sample was prepared by placing a single-analgesic tablet in a small beaker and adding 10 mL of methanol. After allowing the sample to dissolve, the contents of the beaker, including the insoluble binder, were quantitatively transferred to a 25-mL volumetric flask and diluted to volume with methanol. The sample was then filtered, and a l.00-mL aliquot was transferred to a 10-mL volumetric flask and diluted to volume with methanol. When analyzed by HPLC, the signal for the caffeine was found to be 21 469. Report the parts per million of caffeine in the analgesic tablet.

The amount of caffeine in an analgesic tablet was determined by HPLC using a normal calibration curve. Standard solutions of caffeine were prepared and analyzed using a 10-uL fixed-volume injection loop. Results for the standards are summarized in the following table. Concentration, ppm 50.0 Peak Area 8 354 100.0 16 925 150.0 25 218 200.0 33 584 250.0 42 002 The sample was prepared by placing a single-analgesic tablet in a small beaker and adding 10 mL of methanol. After allowing the sample to dissolve, the contents of the beaker, including the insoluble binder, were quantitatively transferred to a 25-mL volumetric flask and diluted to volume with methanol. The sample was then filtered, and a l.00-mL aliquot was transferred to a 10-mL volumetric flask and diluted to volume with methanol. When analyzed by HPLC, the signal for the caffeine was found to be 21 469. Report the parts per million of caffeine in the analgesic tablet.

Chemistry

9th Edition

ISBN:9781133611097

Author:Steven S. Zumdahl

Publisher:Steven S. Zumdahl

Chapter11: Properties Of Solutions

Section: Chapter Questions

Problem 109AE: Patients undergoing an upper gastrointestinal tract laboratory test are typically given an X-ray...

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