Becker's World of the Cell (9th Edition)
Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 25, Problem 25.4CC
Summary Introduction

To determine: Whether the given information can be used to determine the order of genes A, B, and C on the same chromosome.

Introduction: Genes lying closely together on the same chromosome can be used to observe a pattern of segregation. Experiments conducted on fruit flies by Morgan depicted that the distance between the two genes lying on the same chromosome may give a measure of the frequency of their recombination. Genes lying far apart from each other show more chances of being separated by a crossover.

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Suppose researchers studied the first chromosome of a new species and mapped three genes of interest, indicated as a, b, and c. A three‑factor cross was performed and the number of gametes formed from the F2 generation was recorded in a table. Note that the order of genes in the table is arbitrary. Calculate the recombination frequencies for each given gene pair in map units. ?+ ?+ ?+ ? ? ? ? ?+ ?+ ?+ ? ? ? ?+ ? ?+ ? ?+ ? ? ?+ ?+ ?+ ? 173 176 35 33 11 10 3 1 After completing the gene mapping, the researchers treated individuals to induce inversions in the chromosomes. After treatment, another three‑factor cross was performed and the number of gametes formed from the F2 generation was recorded in a second table. Note that the order of genes in the table is arbitrary. ?+ ?+ ?+ ? ? ? ? ?+ ?+ ?+ ? ? ? ?+ ? ?+ ? ?+ ? ? ?+ ?+ ?+ ? 188 185 24 26 1 0 49 46 Calculate the recombination frequencies for each given gene pair in map units.
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